Voxel-based morphometry (VBM) in unilateral mesial temporal lobe epilepsy (mTLE): Volume loss beyond the seizure onset zone and neuropsychological implications
N Embacher, C Brenneis, I Unterberger, J Dobesberger, G Walser, K Egger, T Trieb, M Delazer, T Benke, M Ortler, E Trinka · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Recent studies in mTLE showed by means of EEG, MRI and FDG-PET structural or functional abnormalities outside the seizure onset-zone. Recent voxel-based morphometry (VBM)-studies were able to show hippocampal degeneration in mesial temporal lobe epilepsy (mTLE) patients, however, there was also marked extrahippocampal loss of brain volume. This VBM-study aimed to depict volume loss outside the seizure focus and to correlate neuropsychological deficits. Voxel-wise parametric statistical tests which compare the smoothed gray-matter images from two groups were performed. We applied an optimized VBM protocol on high…
