Effects on cerebrospinal fluid biomarkers in multiple sclerosis patients after repeated intrathecal triamcinolone acetonid application
M Abu-Mugheisib, H Tumani, F Kamin, A Apel, W Köhler, F Hoffmann, R Benecke, UK Zettl · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: This pilot study wanted to characterize the effects on cerebrospinal fluid (CSF) Tau protein, S-100, interleukin (IL) -6-type cytokine, beta-trace protein (beta-trace) and beta-2 microglobulin (beta 2MG) induced by repeated intrathecal triamcinolone acetonid (TCA) applications in multiple sclerosis patients. Methods: In this prospective pilot study 10 patients suffering from Multiple Sclerosis(MS) (4 relapsing remitting [RR], 6 secondary or primary progressive [SP/PP]) were included. Three TCA applications were performed as part of an ongoing trial every second day to reduce spasticity. Results: The m…