CareLit Fachartikel

Role of the CD26/ADA/adenosine system in viral and autoimmune chronic liver disease

F Broelsch, F Jeffe, M Cornberg, V Schlaphoff, MP Manns, H Wedemeyer · Zeitschrift für Gastroenterologie · 2007 · Heft 09

Dokument
1076262
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
F Broelsch, F Jeffe, M Cornberg, V Schlaphoff, MP Manns, H Wedemeyer
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-05 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-988546

Zusammenfassung

Introduction: The cell-surface glycoprotein CD26 has multiple functions including dipeptidyl aminopeptidase (DPP IV) activity, delivery of co-stimulatory T cell activation signals and binding of adenosine deaminase (ADA). ADA displays immunoregulatory functions by inhibiting adenosine which can deliver negative signals on various immune cells. High levels of CD26 can be found on activated T cells and CD26 expression has been linked to autoimmune diseases. The role of the CD26/ADA/adenosine system in regulating immune responses in liver diseases is completely unknown. Methods: We studied CD26 expression on PBMC s…

Schlagworte

Adenosine Hepatitis Autoimmune Hepatitis Adenosine Deaminase Autoimmune Diseases Coformycin Bilirubin Antigens Aminopeptidase Zeitschrift für Gastroenterologie