The CC chemokine RANTES (CCL5) mediates liver fibrosis in mice and humans
ML Berres, A Rüland, M Moreno Zaldivar, D Scholten, N Gaßler, C Weber, C Trautwein, HE Wasmuth · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Chemokines are inflammatory mediators during acute and chronic liver injury. The chemokine RANTES (CCL5) directs lymphocytes to inflamed tissues and directly activates hepatic stellate cells in vitro through interaction with CCR5. These functions define RANTES as an interesting target for antifibrotic therapies. We here present data defining the role of RANTES in human and murine liver fibrosis. Methods: In humans, a haplotype analysis with all tagging RANTES SNPs from the HapMap project was performed in 260 individuals with chronic hepatitis C (HCV). The mRNA expression of RANTES was analysed in HCV infec…
