The Oncolytic Adenovirus Adp53-sensor Replicates Selectively in p53-altered Tumor Cells and Potential Tumor Spectrum is not Limited by the p73 Status

Oncolytic virotherapy provides a promising and novel mean for the treatment of solid tumors. Major challenges in virotherapy are tight restriction of viral replication to malignant cells and a broad range of potential target tumors. The aim of the study was the establishment of a conditionally replicating adenovirus able to recognize the transcriptional p53-status of target cell and able to consequently respond by the selective onset of viral replication in cells lacking functional p53. We constructed Adp53-sensor harboring E1A controlled by a GAL4-binding CMV-promoter and the GAL4KRAB-repressor controlled by th…