Neutralizing Host Responses in Hepatitis C Virus Infection Target Viral Entry at Post-Binding Steps and Membrane Fusion
A Haberstroh, EK Schnober, EK Schnober, P Carolla, B Gißler, MB Zeisel, H Barth, HE Blum, FL Cosset, G Koutsoudakis, R Bartenschlager, E Depla, A Owsianka, AH Patel, C Schuster, F Stoll-Keller, M Doffoël, M Dreux, TF Baumert · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatitis C virus (HCV) is a leading cause of chronic hepatitis worldwide. Viral attachment and entry–representing the first steps of the virus with the host cell interaction- are major targets of adaptive host cell defences. The mechanisms of antibody-mediated neutralization by the host neutralizing responses in HCV infection are only poorly understood. Retroviral HCV pseudotypes (HCVpp) have been successfully used to study viral entry and antibody-mediated neutralization. In this study, we used this model system to study the mechanism of antibody-mediated neutralization by monoclonal anti-envelope antibodies a…
