CareLit Fachartikel
Hepatitis B Virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans
A Schulze, S Seitz, P Gripon, S Urban · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Dokument
1076565
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Jahr
2008
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Zusammenfassung
Contrary to many other viruses, the initial steps of the Hepatitis B virus (HBV) infection, including attachment, specific receptor interaction and membrane fusion, are unsolved. Using the susceptible HepaRG cells as an in vitro cell culture system, we here report that HBV entry into hepatocytes requires the large envelope protein (L)-dependent interaction with cell-surface glycosaminoglycans (GAG). HBV infection was abrogated by incubation of virions with heparin, but not with lower sulfated GAGs. Polycationic substances prevented infection as well, however by addressing cellular components. Enzymatic removal o…
Schlagworte
HBV
HBV infection inhibition
HBV receptor
HepaRG cell line
Hepatitis B Virus
glycosaminoglycan
heparin
Zeitschrift für Gastroenterologie
