Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy – A comparison between clinical subtypes and correlations with clinical parameters
M Minnerop, K Specht, J Ruhlmann, N Schimke, M Abele, A Weyer, U Wüllner, T Klockgether · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2008 · Heft 02
Bibliografische Angaben
Zusammenfassung
Multiple system atrophy (MSA) is a neurodegenerative disease affecting basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord. Clinically, a cerebellar (MSA-C) and a parkinsonian variant of MSA (MSA-P) are distinguished. We used voxel-based morphometry (VBM) and voxel-based relaxometry (VBR) in 48 MSA patients (32 MSA-C, 16 MSA-P) and 46 controls. In MSA-C, VBM revealed gray matter loss in cerebellum, right thalamus, both putamina and several cortical regions including insular cortex. Gray matter loss in the cerebellum and insular cortex was correlated with disease duration a…
