Low-frequency rTMS of the vertex in the prophylactic treatment of migraine

Background: High-frequency rTMS increases and low rTMS frequency decreases neural excitability. Clinically, rTMS shows beneficial effects in the treatment of neurological and psychiatric disorders. Furthermore, chronic and neuropathic pain have been shown to respond to rTMS treatment. A small sized pilot study revealed prophylactic effects of rTMS in migraine. As there is evidence for neuronal hyperexcitability in migraine we conducted this placebo-controlled and blinded study to evaluate the therapeutic effects of a low-frequency rTMS in migraine. The primary endpoint was defined as a significant reduction of m…