Cortical spreading depression of vascular low-frequency fluctuations in patients with Subarachnoid Haemorrhage

It has been suggested that vascular low-frequency fluctuations reflect a brain default mode and they are used to study topography of dysfunction in neurological and psychiatric diseases with functional MRI. Progressive ischaemic damage in the human brain is associated with cortical spreading depolarisations (CSD) leading to depression of the default mode. In a proof of concept approach, we here investigated whether cortical spreading depression of vascular low-fequency fluctuations accompanies CSD independently of whether hyperperfusion (normal coupling), no change of regional cerebral blood flow (rCBF) (uncoupl…