The high mobility group a1 protein – a new regulator of PPARgamma-dependent gene transcription in vascular smooth muscle cells

Objectives: Recently, PPARgamma (peroxisome proliferator-activated receptor gamma) ligands have been shown to exert deleterious cardiovascular side effects. In order to develop new PPARgamma-ligands with improved clinical safety the molecular basis for PPARgamma-activation in cardiovascular cells has to be understood. The present study aimed to identify new nuclear cofactors for PPARgamma-dependent gene transcription in human aortic smmoth muscle cells (HASMC). Results: Using an – Oligo GEArray® Human Nuclear Receptors and Coregulators Microarray (Superarray®) – for gene expression profiling in unstimulated HASM…