Interleukin-1β is a positive regulator of TIARP/STAMP2 in 3T3-L1 adipocytes

Tumor necrosis factor alpha-induced adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) has been characterized as an adipocyte-expressed protein which might play a crucial role in metabolic homeostasis and inflammatory pathways. In the current study, the impact of insulin resistance-inducing and proinflammatory interleukin (IL)-1β on TIARP/STAMP2 gene expression was determined by quantitative real-time reverse transcription-polymerase chain reaction in 3T3-L1 adipocytes. Interestingly, TIARP/STAMP2 mRNA synthesis was significantly stimulated by IL-1β in a dose-dependent fashion with…