PPARgamma activation reduces T-lymphocytes infiltration in adipose tissue

The peroxisome proliferator-activated receptor gamma (PPARgamma) is a major regulator of glucose and lipid metabolism. Furthermore PPARgamma was identified as a key player in inflammation and the development of cardiovascular disease. The role of PPARgamma may expand beyond its primary action in adipose tissue, and involve the regulation of lymphocyte and macrophage infiltration into adipose tissue. To determine the functional significance of PPARgamma activation in the developement of insulin resistance and adipose tissue inflammation in vivo we undertook studies in HFD (60% kcal from fat)-fed C57BL/6J mice tre…