Therapeutic hypothermia in neonates: Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units
T Höhn, G Hansmann, C Bührer, G Simbruner, A Gunn, J Yager, M Levene, S Hamrick, S Shankaran, M Thoresen · Zeitschrift für Geburtshilfe und Neonatologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
Recent evidence suggests that the current ILCOR guidelines regarding hypothermia for the treatment of neonatal encephalopathy need urgent revision. In 2005 when the current ILCOR guidelines were finalized one large (n=235) and one small RCT (n=67), in addition to pilot trials, had been published. Each suggested that therapeutic hypothermia after perinatal asphyxia was effective and safe. A subsequent whole body cooling trial supported by the NICHD also showed a positive effect on outcome with a NNT of 6. Further large neonatal trials of hypothermia have stopped recruitment for different reasons and their final r…
