AGO-Cervix-1 study: A prospective, randomized phase III study to compare the effects of Paclitaxel and Topotecan to those of Cisplatin and Topotecan for treatment of patients with…

In patients with recurrent, persistent, or metastasized cervical cancer for which a curative treatment by operation and/or radiation therapy is not possible chemotherapy is an option. But up to 75% of all these patients are assumed to have already been treated with cisplatin in conjunction with radiation therapy. It seems questionable to continue to treat the patients with cisplatin. The studies GOG 169 and 179 demonstrated that a combination of paclitaxel and cisplatin was superior to a cisplatin monotherapy with respect to therapeutic response and progression-free survival, as was a combination of topotecan an…