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ATG16L1 and IL-23 receptor (IL-23R) genes are associated with disease susceptibility in Hungarian CD patients

P Lakatos, T Szamosi, A Szilvasi, E Molnar, L Lakatos, A Kovacs, T Molnar, I Altorjay, M Papp, K Palatka, Z Tulassay, P Miheller, J Papp, T Attila, H Andrikovics · Zeitschrift für Gastroenterologie · 2008 · Heft 05

Dokument
1077096
CareLit-ID
Jahr
2008
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
P Lakatos, T Szamosi, A Szilvasi, E Molnar, L Lakatos, A Kovacs, T Molnar, I Altorjay, M Papp, K Palatka, Z Tulassay, P Miheller, J Papp, T Attila, H Andrikovics
Ausgabe
Heft 05 / 2008
Seiten
–
Erschienen: 2008-05-15 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2008-1079656

Zusammenfassung

Background: North American and European genome wide association scans identified ATG16L1 and IL23R as novel inflammatory bowel disease (IBD) susceptibility genes and subsequent reports confirmed in large independent populations. The aims of this study were to investigate the association and examine genotype-phenotype relationships in a Hungarian IBD cohort. Methods: 415 unrelated IBD patients (CD: 266, age: 35.2±12.1 years, duration: 8.7±7.5 years and UC:149, age: 44.4 ±15.4 years, duration: 10.7±8.9 years) and 135 healthy subjects were investigated. IL23 Arg381Gln (R381Q,rs11209026) and ATG16L1 Thr300Ala (T300A…

Schlagworte

Zeitschrift für Gastroenterologie