CareLit Fachartikel
HGF/c-Met and IL-6/gp130 cooperatively regulate liver homeostasis and antibacterial signalling after bile-duct-ligation
A Giebeler, S Erschfeld, C Birchmeier, C Trautwein, KL Streetz · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Dokument
1077337
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: HGF/c-Met and IL-6/gp130 play a crucial role as mediators of cellular survival and protection in the liver. Here we aimed to analyse its interactions on a cellular level in a model of acute cholestatic liver injury induced bile-duct-ligation (BDL). Material and Methods: Hepatocyte specific(Δhepa) conditional knockout mice (Cre-loxP system) for c-Met, gp130 and c-Met/gp130 were subjected to BDL. Results: Gp130Δhepa and the c-Met/gp130Δhepa mice displayed more then 50% mortality during the first 7d after BDL, while WT and c-MetΔhepa mice survived. To analyse if septicaemia is responsible for the observed rap…
Schlagworte
BDL
HGF
IL-6
Liver
STAT3
Sepsis
TLR4
c-Met
conditional knockout
gp130
Zeitschrift für Gastroenterologie
