CareLit Fachartikel
Wisp1, a new marker of hepatocellular carcinoma?
S Lukowski, I Ilkavets, HL Weng, S Dooley · Zeitschrift für Gastroenterologie · 2010 · Heft 01
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1077345
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Jahr
2010
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Zusammenfassung
Hepatocarcinogenesis is a multistep process. There is evidence that its development and progression is caused by genomic and epigenomic alterations that induce or repressexpression of cancer-related genes. Among oncogenic pathways implicated in malignant transformation of liver cells, the transforming growth factor-beta (TGF-β) pathway is of particular relevance. Following a microarray screen covering the whole mouse genome of TGF-β1 treated versus control samples, we identified TGF-β dependent upregulation of WNT-1-induced secreted protein 1 (Wisp-1) expression, a member of the family containing CTGF, Cyr61 and…
Schlagworte
HCC
Hepatocarcinogenesis
TGF-β
apoptosis
hepatocytes
proliferation
Zeitschrift für Gastroenterologie
