Tailoring of hepatitis C virus escape from an HLA-B27 restricted CD8+ T cell epitope
C Neumann-Haefelin, C Oniangue-Ndza, T Kuntzen, MW Kemper, KA Power, S Ingber, LL Reyor, K Hills-Evans, AY Kim, GM Lauer, R Thimme, TM Allen · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatitis C virus (HCV) evades from approximately half of the specific CD8+ T cell responses by viral escape mutations. The need to escape from T cell pressure and viral fitness costs resulting from potential escape mutations are conflicting forces, and may lead to different patterns of escape mutations within infected individuals. Here, we analyzed the tailoring of viral escape within an HLA-B27 restricted epitope (NS5B 2937–2944, GRAAICGKY) by combining viral sequence analysis in a large cohort of patients, viral fitness analysis in a subgenomic HCV replicon system, and functional T cell assays. Two viral esca…
