The strength of the Fas ligand signal determines whether hepatocytes act as type-1 or type-2 cells in murine livers
S Schüngel, LE Buitrago-Molina, P Nalapareddy, M Lebofsky, A Gross, M Manns, H Jaeschke, A Vogel · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Apoptosis induced by Fas activation has been implicated in a variety of liver diseases.1,2 Binding of the FasL to its receptor triggers intracellular activation of caspase-8.3–6 In type I cells caspase-8 activates the effector caspases which suffices to kill the cell. In type II cells caspase-8 requires a mitochondria-amplification loop to induce cell death.7,8 Bid was identified to mediate the apoptotic signal from the cell surface to the mitochondria.9 Bid has been shown to be critical for Fas-induced apoptosis in hepatocytes, which are therefore regarded as type II cells. Furthermore, some studies have sugges…
