Characterization of melatonin receptors (MT1 and MT2) in rat and human pancreata

Introduction: Numerous studies recently provided evidence for an interrelationship between melatonin and insulin. Perifusion experiments with rat islets of Langerhans demonstrated, that the insulin secretion exhibits a circadian rhythm, which could be phase-shifted after melatonin application. Furthermore, in vitro and animal investigations established, that melatonin inhibits the insulin secretion. Aim of the present study was the analysis of melatonin receptors as possible mediators of melatonin action in pancreatic tissue of rats and humans as well as the characterization of melatonin receptors of non diabeti…