Temporal dynamics of motor integration in Parkinson's disease: towards a concept of time-frequency coding in cortico-basal networks

Introduction. Intraoperative recordings of oscillatory activity from the left subthalamic nucleus (STN), EEG and right forearm EMG (flexor digitorum muscle (FD), extensor digitorum muscle (ED)) were performed in six PD patients during surgery for STN-DBS in order to comprehensively study temporal dynamics of motor integration in distributed networks including STN, M1, and contralateral effector muscles. Material and Methods: Randomised and externally paced finger movements of the right fingers 2–5 were performed. Temporal dynamics were quantified in terms of short time Fourier transform and event-related coheren…