InsR/FoxO1 signaling affects neuroanatomy of hypothalamic POMC neurons

The insulin-regulated transcription factor FoxO1 functions as a major metabolic integrator in the hypothalamic feeding center and controls melanocortinergic tone. By inhibiting FoxO1, Insulin receptor (InsR) signaling regulates gene transcription in hypothalamic POMC neurons. While a role of InsR/FoxO1 signaling in the development of neuronal feeding circuits in the hypothalamus has become evident, knowledge about the underlying mechanisms remains vague. Many studies have investigated the role of the maternal environment in this context, but the role of InsR/FoxO1 signaling in hypothalamic POMC neurons themselve…