DNA methylation in AT/RT

Introduction: AT/RT tumors are highly malignant often chemoresistant neoplasms mainly affecting infants and young children. Epigenetic mechanisms such as hypermethylation of tumorsuppressor genes may be reversible and are therefore interesting possible therapeutic targets. The aim of this work was to investigate whether there can be found hypermethylation of known candidate genes in AT/RT. Methods: Methylation of candidate genes were evaluated in 5 cell lines derived from rhabdoid tumors (2 AT/RT, 2 renal rhabdoid cell lines and one extrarenal, extracranial cell lines), as well as in more than 14 primary AT/RT u…