CareLit Fachartikel

Impact of IL28B-genotype on virological response in treatment-naive Austrian patients with chronic hepatitis C

A Staettermayer, K Rutter, S Beinhardt, TM Scherzer, K Zinober, R Stauber, C Datz, A Maieron, M Gschwantler, H Kessler, H Laferl, P Steindl-Munda, H Hofer, P Ferenci · Zeitschrift für Gastroenterologie · 2010 · Heft 05

Dokument
1077791
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Staettermayer, K Rutter, S Beinhardt, TM Scherzer, K Zinober, R Stauber, C Datz, A Maieron, M Gschwantler, H Kessler, H Laferl, P Steindl-Munda, H Hofer, P Ferenci
Ausgabe
Heft 05 / 2010
Seiten
–
Erschienen: 2010-05-07 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1254636

Zusammenfassung

Background and Aim: A genome wide association screening in patients participating in the IDEAL trial revealed a SNP in the IL28B-gene which predicted outcome of antiviral treatment in chronic hepatitis C patients with genotype (GT) 1 (Ge D et al., Nature Gen 2009). The aim of this study was to investigate the role of this polymorphism on virological response in treatment-naïve Austrian patients participating in published randomized controlled trials (GT1: J. Hep 2006, GT 2/3: Hepatology 2008, GT 1/4:Gastroenterology 2009). Methods: DNA was obtained from 682 patients. The rs12979860 region of the IL28B-gene was i…

Schlagworte

Zeitschrift für Gastroenterologie