Effect of rectal indomethacine in the prevention of post-ERCP pancreatitis

Background: The results of studies investigating the role of prophylactic nonsteroideal antiinflammatory drugs for the reduction of the risk of post-ERCP pancreatitis are inconclusive. Aim: To asses the efficacy of rectal indomethacine for the prevention of post-ERCP hyperamylasaemia and pancreatitis. Methods: A prospective randomised trial was conducted in 107 consecutive eligible patients (67 women and 40 men, mean age 66.1±16.5 years), who underwent ERCP. 62 patients received rectal suppositories of 100mg indomethacine 10min before starting the investigations. Exclusion criteria were previous endoscopic sphin…