Acquired factor IX inhibitor in a patient with cerebral and retroperitoneal haemorrhage after successful treatment of chronic hepatitis C (CHC) with peginterferon-alfa (PEG-IFN-α)…

Introduction: An acquired factor (F) VIII inhibitor in a pt without haemophilia A is a very rare disorder. Chronic HCV infection can have extrahepatic manifestations, especially autoimmune disorders, antibody formation and haematologic complications. Two case reports have described the occurrence of an acquired F VIII inhibitor in pts with CHC without exposure to IFN-α. Another case report described a pt with haemophilia A and HCV infection who developed an acquired F VIII inhibitor after treatment with IFN-α. The literature makes no mention of the production of F IX inhibitor in relation to CHC or treatment wit…