Small bowel enteropathy associated with NSAID therapy. experiences with capsule endoscopy

Background and Aims: Conventional nonsteroidal anti-inflammatory drugs (NSAID) and also cyclooxygenase-2 enzyme (COX-2) inhibitors result small bowel damage in man either during a short-term or long-term treatment period. Capsule endoscopy (CE) method is an emerging technique for assessing small bowel damage. Using CE small bowel changes were found up to 70% of the patient taking NSAIDs or COX-2 inhibitors with over a third having mucosal breaks (erosive-ulcerative mucosal lesions). The precise pathogenesis is uncertain but it seems likely that local topical effects involving NSAID-membrane phospholipids interac…