Panobinostat induces cell death through Endoplasmic Reticulum stress in hepatocellular cancer cells

Aims: Panobinostat (LBH589), a pan-deacetylase inhibitor, represents a novel therapeutic option for human cancer diseases. We have previously shown that panobinostat has a potent apoptotic activity in vitro and causes a significant growth delay of hepatocellular carcinoma (HCC) tumor xenografts in nude mice models. We have demonstrated that treatment with panobinostat is able to induce cell death in HepG2 (p53wt) and in Hep3B (p53null) cell lines that, interestingly, is not dependent on canonical apoptotic pathways. Here we analyse the involvement of Endoplasmic Reticulum (ER) in cell death induced by panobinost…