Investigation of the PRSS1 and SPINK1 genes in patients with autoimmune pancreatitis from Germany

Introduction: Genetic mutations in the PRSS1, SPINK1 and CFTR genes have been associated with chronic pancreatitis. The frequency of genetic variations in these genes has not been determined in patients with autoimmune pancreatitis (AiP) from Germany. Objectives: To identify the frequency of PRSS1 and SPINK1 mutations in patients with AiP from Germany. Methods: Mannheim AiP Diagnostic Criteria define „definite“, „probable“ and „possible“ AiP. „Mannheim Definite AiP“ is diagnosed in patients fullfilling Mayo HISORt or Asian AiP Criteria; or simultaneously presenting with pancreatic disease, other autoimmune disea…