Genetic modifiers of the effect of menopausal hormone therapy on breast cancer risk – A meta-analysis of four genome-wide association studies
R Hein, L Beckmann, K Czene, P Hall, A Kresentia, S Lindström, J Liu, H Nevanlinna, L Yuqing, N Dahmen, D Flesch-Janys, J Chang-Claude · Das Gesundheitswesen · 2010 · Heft 09
Bibliografische Angaben
Zusammenfassung
Hormone therapy (HT) is associated with an elevated risk of breast cancer (BC) in postmenopausal women. Only limited studies have examined whether BC risk after HT exposure varies by individual susceptibility. To identify loci that modify HT related BC risk, four genome-wide case-only studies were analysed separately and combined in a meta-analysis. We included data from the genome-wide association studies HEBCS (Finland), MARIE (Germany), NHS (USA) and SASBAC (Sweden) which yielded 344, 742, 1,090 and 773 female, postmenopausal BC cases, respectively. Recruitment was hospital-based for HEBCS and population-base…
