Associations between variations in the TLR4 gene and incident coronary heart disease (CHD) in middle-aged men and women: Results from the MONICA/KORA Augsburg case-cohort study, 1…
M Karakas, J Baumert, M Müller, N Klopp, B Thorand, D Meredith, C Meisinger, C Herder, T Illig, W Koenig · Das Gesundheitswesen · 2010 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Toll-like receptor 4 (TLR4), the signalling receptor for lipopolysaccharides, is an important member of the innate immunity system. Since several studies have suggested that atherosclerosis might be associated with changes in the innate immune response, and a SNP in the TLR4 gene (Asp299Gly; Kiechl et al, N Engl J Med 2002;347:185–92) was shown to be associated with a decreased risk of atherosclerosis, we sought to investigate the impact of gene variants in the TLR4 gene on incident CHD. Methods: A case-cohort study was conducted in initially healthy, middle-aged men and women based on data from the…
