Heparin-polynitroxide derivatives: first application as site specific MRT imaging contrast media for vascular wall
MV Terekhov, V Sen, V Golubev, S Weber, AW Scholz, T Muenzel, AL Kleschyov, LM Schreiber · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · Heft 11
Bibliografische Angaben
Zusammenfassung
Aim: Cyclic nitroxides e.g. TEMPO are stable free radicals with multiple applications in MRI. Heparin is known to have a high affinity for the vascular extracellular structures. We propose that TEMPO could be delivered to the vascular wall by means of heparin-polynitroxide (HNR) derivatives where the nitroxide is linked with the heparin. The T1,2 measurements show that HNR complexes provide the relaxivity contrast comparable with Gd-based media. The particular motivation of this work were proof of principal experiment for using HNR as a new biomarker with contrast media and protective antioxidant activity effect…
