CareLit Fachartikel
Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates hepatic inflammation and fibrosis in experimental NASH but protects against bile duct ligation induced liver fibrosis
K Dostert, C Hellerbrand, E Gäbele · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
1078452
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: Non alcoholic steatohepatitis (NASH) leads to liver fibrosis characterized by activation of hepatic stellate cells (HSC) and enhanced collagen expression. We were able to show that PI3K, an ubiquitary heterodimeric lipid kinase, participates in HSC proliferation and collagen expression. Therefore, the aim of this study was to evaluate the role of PI3K in experimental NASH and biliary fibrosis. Methods: PI3K knockout mice (PI3K-/-, C57Bl/6 background) and C57Bl/6 wild-type control mice (WT) were allocated to 4 experimental groups (n=6) receiving either standard chow (SC) or a high fat (HF) diet according. I…
Schlagworte
NASH
PI3-kinase
liver fibrosis
steatosis
Diet
Phosphatidylinositol 3-Kinase
Diagnosis
Actin
Zeitschrift für Gastroenterologie
