CareLit Fachartikel

The ubiquitin ligase SIAH-1 mediates overexpression of nucleic-acid binding protein FBP-3 and promotes HCC cell proliferation

M Malz, A Brauckhoff, A Weber, J Samarin, MO Riener, C Soll, P Schirmacher, K Breuhahn · Zeitschrift für Gastroenterologie · 2011 · Heft 01

Dokument
1078462
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Malz, A Brauckhoff, A Weber, J Samarin, MO Riener, C Soll, P Schirmacher, K Breuhahn
Ausgabe
Heft 01 / 2011
Seiten
–
Erschienen: 2011-01-13 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0030-1269576

Zusammenfassung

Background/Aims: Far upstream element (FUSE) binding protein (FBP)-1 and FBP-2 are potent regulators of hepatocellular carcinoma (HCC) cell proliferation and cell motility, respectively. In this study we aimed to analyze the expression, functional relevance, and regulation of FBP-3, another FBP family member in human hepatocarcinogenesis. Methods: Expression of FBP-3 was analyzed in normal livers, dysplastic nodules and HCCs. Functional consequences after RNAi-mediated reduction of FBP-3 on HCC cell proliferation, viability, and migration were analyzed. In order to identify potential upstream regulators of FBP-3…

Schlagworte

E3-ubiquitin ligase FUSE-binding protein Hepatocellular carcinoma tumor cell proliferation Zeitschrift für Gastroenterologie