Protective effects of FXR on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
J Schmitt, B Kong, B Stieger, G Guo, O Tschopp, SM Schultze, JC Mertens, P Frei, A Weber, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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Zusammenfassung
Aims: NALFD represents a chronic liver disease and cofactor in other metabolic diseases with worldwide growing incidence. There is growing evidence confirming a functional interaction between FXR-pathways and hepatic triglyceride metabolism. Methods: Liver- and intestine- specific Fxr knockout mice were under 1% cholesterol diet for 28 days. Histological examination of frozen tissue sections included Sudan III/H&E and BODIPY staining. Liver triglycerides, serum cholesterol and serum bile acids were measured. mRNA expression of several genes involved in bile acid homeostasis (Fxr, Shp, Ntcp, Bsep, Cyp7a1 Fgf15),…
