Genetic variation in the human interleukin 4 (IL4) gene is associated with gallstone susceptibility
A Tönjes, A Tönjes, T Strauch, C Ruffert, J Mössner, M Stumvoll, P Kovacs, H Wittenburg · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Quantitative trait locus mapping in the inbred mouse model of cholesterol cholelithiasis identified a gallstone-susceptibility (Lith) locus on mouse chromosome 11, which co-localizes with the Il4 gene. In addition, ablation of Il4 promoted cholesterol gallstone formation in the mouse model of cholelithiasis rendering IL4 an interesting LITH-candidate gene. Methods: To systematically explore the IL4 gene as a LITH gene in humans, we performed a genetic association study in gallstone carriers (N=184) and control subjects without evidence for gallstones (N=833) from a self-contained population of Sorb…
