Effect of acute-phase cytokines on gene expression of DOR and other thyroid hormone receptors in rat liver and cultured liver cells

Non-thyroidal-illness (NTI) is characterized by low tri-iodothyronine (T3) serum level under acute-phase-conditions. We studied hepatic gene expression of newly identified thyroid hormone receptor (TRs) cofactor DOR/TP53INP2 together with TRs in a model of aseptic abscesses induced by injecting intramuscular turpentine-oil (TO) in each hind limb. Liver cells (hepatocytes, macrophages and (myo)fibroblasts) were isolated from normal rat liver and treated with acute-phase cytokines. Hepatocytes were further treated with T3 in the presence or absence of IL-6.A fast (4–6h) decrease in serum-level of free thyroxine (F…