Molecular Targets in Embryonal Tumors

Molecular profiling studies have the potential to describe the complexity of cancer genotypes and phenotypes, and provide an opportunity to link signalling pathway deregulation with potential therapeutic strategies. High-throughput genomic, proteomic and epigenomic data have expanded our knowledge of oncogenic pathways and their functional roles and interactions in embryonal tumors. We preclinically assessed the suitability of selected targets identified within these signalling pathways for novel therapeutic approaches in vitro and in vivo. Molecular targets identified in our profiling studies of neuroblastoma a…