Enhancing Cytotoxicity of Cytokine-Induced Killer (CIK) Cells against Refractory Leukemia
E Rettinger, S Kuçi, Z Kuçi, G Weber, A Willasch, H Kreyenberg, U Koehl, D Von Laer, S Fulda, T Klingebiel, P Bader · Klinische Pädiatrie · 2010 · Heft 12
Bibliografische Angaben
Zusammenfassung
Haploidentical stem cell transplantation (SCT) has become an important treatment modality for patients with high-risk acute leukemia. Nevertheless, the therapeutic success is still mainly affected by relapse. Cytokine-induced killer (CIK) cells may serve as an alternative approach to adoptive donor lymphocyte infusions (DLI) in cases of impending relapse. In this study, we investigated the feasibility of generating CIK cells for adoptive immunotherapy after haploidentical transplantation. We analyzed the cytotoxic potential of CIK cells against CML and AML as well as T- and B-ALL cell lines. Notably, cytotoxic a…
