Multi-tracer microPET imaging of a mouse model of Alzheimer's disease to assess microglial activation and anti-inflammatory treatment
S. Rapic, H. Backes, T. Viel, P. Monfared, B. Neumaier, S. Vollmar, M. Hoehn, A. Van der Linden, M.T. Heneka, A.H. Jacobs · Klinische Neurophysiologie · 2011 · Heft 03
Bibliografische Angaben
Zusammenfassung
Introduction: In Alzheimer's disease (AD), activated microglia play an important role in amyloid clearance and secretion of pro-inflammatory molecules that lead to chronic neuroinflammation. The nuclear peroxisome proliferator-activated receptor γ (PPAR-g) is involved in the regulation of inflammatory processes at transcriptional level. Aim: To determine whether microglial activation as assessed by micro-positron emission tomography (mPET) employing PK11195 as specific marker for activiated microglial cells is altered in APPSwe/PS1dE9 transgenic (Tg) mice as compared to C57BL/6J wild type (Wt) mice and whether e…
