CareLit Fachartikel

Partial or multi drug resistant NB cell lines are highly sensitive towards chimeric receptor expressing NK-92-scFv(ch14.18)-zeta

D Seidel, A Shibina, CP Reynolds, WS Wels, HN Lode, N Huebener · Klinische Pädiatrie · 2011 · Heft 05

Dokument
1078832
CareLit-ID
Jahr
2011
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
D Seidel, A Shibina, CP Reynolds, WS Wels, HN Lode, N Huebener
Ausgabe
Heft 05 / 2011
Seiten
–
Erschienen: 2011-05-05 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1277096

Zusammenfassung

Introduction: The treatment of high-risk NB patients is still challenging, due to partial or multi-drug resistance (MDR) in relapsed tumors. Therefore we investigated the efficacy of GD2-specific NK-92 (NK-92tr) towards relapse NB cell lines. Aims and Methods: We compared cell lines established at time point of diagnosis with their respective relapse cell line in Cr51 release cytotoxicity assays. GD2 expression on cell lines from diagnosis and relapsed tumor were compared, using flow cytometry (FC). Homing characteristics and in vivo efficacy towards relapse cell line CHLA-20 were analyzed in a xenograft mouse m…

Schlagworte

Klinische Pädiatrie