Changes in element homeostasis during cisplatin treatment in different organs

Introduction: Cisplatin is a platinum complex widely used as an active anticancer agent in testicular, ovarian and bladder carcinomas, head and neck squamous cell carcinoma, and non-small cell lung cancers. Pt complexes are well-known DNA-alkylating agents and their interaction with proteins may be part of a series of molecular events. Pt compounds can modulate signal transduction routes and induce apoptotic responses. Pt complexes have serious side effects and resistance phenomena. Aims: Cisplatin is significantly metabolized in the liver and excreted through the kidney but the kidney is also the primary site o…