Association between IL28B CC genotype and increased TNF-alfa and IL-2 production of peripheral blood mononuclear cells in patients with chronic hepatitis C virus (HCV) infection
G Pár, T Berki, L Palinkas, P Kisfali, B Melegh, L Szereday, B Hunyady, Á Vincze, A Pár · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background/Aims: Recently IL28B rs12979860 CC genotype as the strongest pretreatment predictor of SVR has been described in HCV genotype 1 patients treated with pegylated interferon and ribavirin. IL28B CC genotype is known to be associated with improved early viral kinetics and greater likelihood of rapid virological response (RVR) compared with CT or TT genotypes. Earlier we demostrated pretreatment TLR4 activation induced TNF-alfa production of the monocytes is significantly higher in RVR patients compared to non-responders. Aim of the present study was to compare cytokine production of patients with IL28B CC…
