Image-guided Polymeric Nanomedicines for Radiochemotherapy

Drug targeting systems are nanometer-sized carrier materials designed for improving the biodistribution of systemically applied (chemo-) therapeutics. Reasoning that I) the temporal and spatial interaction between i.v. applied weekly chemotherapy and clinically relevant daily radiotherapy is suboptimal, and that II) drug targeting systems are able to improve the temporal and spatial parameters of this interaction, we have recently set out to evaluate the potential of 'carrier-based radiochemotherapy'. HPMA copolymers were used as a model drug targeting system, doxorubicin and gemcitabine as model drugs, and the…