CareLit Fachartikel
Broad spectrum assessment of resistance phenomena to virotherapeutics
M Noll, S Berchtold, J Lampe, M Bitzer, UM Lauer · Zeitschrift für Gastroenterologie · 2011 · Heft 08
Dokument
1079268
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: Measles vaccine virus (MeV) has proven its oncolytic potential in several tumor models. Nevertheless primary and secondary resistance phenomena often emerge. In order to increase efficiency and to overcome resistance phenomena, a recombinant armed MeV vaccine strain (MeV ld-SCD) was generated. The inserted suicide gene encodes a fusion protein composed both of yeast cytosine deaminase (YCD) and yeast uracil phosphoribosyltransferase (YUPRT), which converts the non-toxic prodrug 5-fluorocytosine (5-FC) into the cytotoxic 5-fluorouracil (5-FU). Because of its ability to diffuse freely, 5-FU can also…
Schlagworte
Tumor
After
Cytosine Deaminase
Bystander Effect
Bystander-Effect
Cytosine
Zeitschrift für Gastroenterologie
