Reduction of intrauterine growth retardation (IUGR) in a high-risk group with the NO-donor penterythriltetranitrat (PETN) – a prospective randomized double-blind placebo trial

Objectives: NO-donors reduce the impedance in uteroplacental vessels (Kähler et al, 2004). Lees et al's pilot study demonstrated that transdermal nitroglycerin positively influences pregnancy outcome within a high-risk collective. Currently, we present the results of a randomized, prospective, and placebo-controlled, double-blind study implemented with the aim to investigate whether the oral NO-donor Pentalong® (PETN) is suitable as a prophylactic drug in abnormal placentation. Methods: We included 111 pregnancies presenting with abnormal placental perfusion (bilateral notch or mean RI>0.7) between the 19th to 2…