Increased expression of the glucose transporter GLUT1 in liver fibrosis
B Czech, D Valletta, M Saugspier, TS Weiss, C Dorn, A Bosserhoff, C Hellerbrand · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
The activation of hepatic stellate cells (HSC) is a key event of hepatic fibrosis. Hyperglycemia is one of the factors known to induce and promote hepatic fibrogenesis, however, mechanisms regulating glucose uptake into HSC have not been studied so far. Normal liver reveals only low expression of the facilitative glucose transporter (GLUT) 1, but its expression is increased in hepatocellular carcinoma (HCC), where GLUT1 has been shown to be a tumor promotor. The aim of this study was to assess GLUT1 expression in liver fibrosis. Methods and Results: Hepatic GLUT1 expression was significantly increased in the bil…
