CareLit Fachartikel
Identification of a novel genetic risk factor for liver fibrosis within the adiponutrin (PNPLA3) pathway: elastography-based study in patients with chronic liver diseases
M Krawczyk, MG Mahler, F Lammert, F Grünhage · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
1079485
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Jahr
2012
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Zusammenfassung
Aims: Lately we have identified the p.I148M adiponutrin (PNPLA3) variant as common genetic risk factor for liver fibrosis1. In humans, PNPLA3 expression is induced by sterol regulatory element binding protein 1c (SREBP1c). Here we investigate two SREBP1c variants (rs2297508 and rs11868035), recently associated with insulin resistance and diabetes2, as genetic determinants for hepatic fibrosis. Patients and methods: We recruited 899 individuals (age 20–86 years, 548 males) with chronic liver diseases (CLD). Liver status was non-invasively phenotyped by transient elastography (TE, Fibroscan). SREBP1c single nucleo…
Schlagworte
adiponutrin
genetic polymorphism
liver fibrosis
Association
Allele
ANOVA
After
Zeitschrift für Gastroenterologie
