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Mapping differential susceptibility of primary hepatocytes to TGF-β in the BXD population of recombinant inbred mouse lines

R Müllenbach, R Hall, S Dooley, F Lammert · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
1079486
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Müllenbach, R Hall, S Dooley, F Lammert
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295766

Zusammenfassung

Aims: TGF-β is the central pro-fibrogenic cytokine in liver, and exerts autocrine effects on neighbouring hepatocytes as well as attracting and activating myofibroblasts. We suspect that differential sensitivity to autocrine TGF-β signalling might be a factor underlying the susceptibility to developing fibrosis in various aetiologies. Hypothesis: Genetic variants causing different hepatocellular sensitivity to TGF-β induced damage might modulate susceptibility to fibrogenesis in response to chronic hepatocellular damage. Methods: We cultured primary hepatocytes from two different inbred laboratory mouse strains,…

Schlagworte

Fibrogenesis TGF-beta hepatocellular damage linkage mouse genetics Population Architecture Chemokine Cytokine After Zeitschrift für Gastroenterologie